Abstract
Cancer is defined as development of number of abnormal cells by uncontrollable cell division leads to the tissue detriment. It has the ability to spread throughout the body. Cancer is second-leading disease to cause the death in the world. Now-a-days survival rate for cancer may increase through the treatment. In this study, the cancer is treated by exploring the anti-oxidant and anti-inflammatory activity of novel Phenothiazines. Because anti-oxidants play a vital role in treatment of cancer by reducing the oxidative stress, abnormal cell division reduction, decrease in DNA damage, and reduced mutagenesis. As we know that NSAIDS (anti-inflammatory drugs) can help in prevention of cancer by inhibiting COX enzyme, increasing apoptosis, reducing cell migration, increasing chemo-sensitivity. Through this study we proved the anti-oxidant and anti-inflammatory activity of newly synthesized phenothiazine derivatives, followed by anti-cancer activity in addition with in-silico molecular docking studies to explore the exact mechanism of action of phenothiazine in cancer treatment.
Published Version
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