Abstract
The pathogenesis of post-kala-azar dermal leishmaniasis (PKDL) is complex. Only 5 to 10% of kala-azar patients develop this dermal complication, and it is not known whether this is due to changes in the parasite genome or some host factors. Here, we report the whole-genome sequence and annotated genes of the whole genome of the PKDL strain.
Highlights
Post-kala-azar dermal leishmaniasis (PKDL) is a well-known dermal sequela of visceral leishmaniasis (VL) or kala-azar
PKDL manifests as maculopapular skin lesions several months or years after the cure of VL, but only in 5 to 10% of patients
Pairwise alignment was performed with Leishmania donovani Ld2001 (4), which showed 6,712 variable sites in the genome of our PKDL isolate with 744 synonymous, 1,068 nonsynonymous SNPs, and 20 frameshift indels
Summary
Post-kala-azar dermal leishmaniasis (PKDL) is a well-known dermal sequela of visceral leishmaniasis (VL) or kala-azar. PKDL manifests as maculopapular skin lesions several months or years after the cure of VL, but only in 5 to 10% of patients. Our group has been of the opinion that PKDL is a result of in vivo generation of quasi-species of Leishmania donovani either as in vivo hybridization of various endemically circulating species within the host cells or due to superinfection with other organisms (1).
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