Abstract
Globally, breast cancer in women has become a major issue of concern, especially with treatment methods that are harmful to the patients. This research involved the trisodium citrate dihydrate (TSCD) reduction and capping of gold nanoparticles (AuNPs) to be used as a drug delivery system for Boswellia sacra (BS) and Commiphora myrrha (CM) to induce cytotoxicity in breast cancer cell lines MCF-7 and MDA-MB-231 without harming MCF-10A healthy cells. Characterization and size of nanoparticles were confirmed by UV-Visible Spectroscopy and Transmission Electron Microscopy. A pristine sample of monodispersed gold nanoparticles from 15-20 nm in size was produced. Pure plant extract was obtained and identification was confirmed using Fourier Transform Infrared Spectrometer and Gas Chromatography Mass Spectrometry. Once synthesized, two concentrations of the compound were sent and tested on breast cancer cell lines MCF-7, MDA-MB-231, and MCF-10A at the Brantley Cancer Research Laboratory at Loma Linda University Health, School of Medicine in Loma Linda, California. Results showed cytotoxicity in both cell lines, more aggressive in triple-negative cells, without harm to healthy MCF-10A cells. Utility Patent has been filed with the USPTO.
Highlights
Throughout the world, breast cancer in women has become a great concern, especially with treatment methods that cause harmful side effects
The aim of this study was to investigate the cytotoxic effect of gold nanoparticles conjugated with Boswellia sacra and Commiphora myrrha extracts on breast cancer cells
While breakthroughs in targeted therapy have emerged in recent years for breast cancer, such therapies have benefited those with breast cancer that express either the estrogen receptor, progesterone receptor or human epidermal growth factor receptor 2 (HER2)
Summary
Throughout the world, breast cancer in women has become a great concern, especially with treatment methods that cause harmful side effects. The Director of the IARC, Dr Christopher Wild, said that “An urgent need in cancer control today is to develop effective and affordable approaches to the early detection, diagnosis, and treatment of breast cancer among women living in less developed countries. Individuals who have been diagnosed with cancer have been treated with surgery, radiation therapy, chemotherapy, hormonal therapy, and targeted therapy (blocking the growth of cancer cells by interfering with specific molecules needed for tumor growth). Current cancer drugs include the following side effects: decreased blood cell counts, mouth ulcers, hair loss, nausea and vomiting, heart damage, allergic reaction, loss of appetite, change in taste, joint pain, numbness or tingling in fingers or toes, diarrhea, photosensitivity, dry skin, labored breathing, kidney damage and more [3]. Chemotherapy kills cancer cells as well as healthy cells, with its host of related side effects
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