Abstract
A novel corona virus named as 2019 n-CoV was identified to be the actual cause of an outbreak of respiratory illness in Wuhan, China beginning in late December 2019. This respiratory disease was named as COVID-19 by WHO. There are many countries affected by COVID-19 including Pakistan. In this review we have provided a brief introduction of COVID-19 and discussed epidemiological and phylogenetic analysis of Pakistani novel corona virus strain. Our epidemiological analysis of data till 16th May 2020 showed rapidly increasing number of new cases, while at the same time a higher recovery rate than number of deaths in Pakistan. Moreover, phylogenetic analysis indicated that 2019-nCoV strain of Pakistan shared 100 % bootstrap value with various countries’ novel corona virus strains. Similarly, phylogenetic analysis was also conducted in comparison with SARS species to confirm our results. In this review, current knowledge of pathogenesis, diagnosis, treatment of COVID-19 and comorbidities which could be helpful in offering novel understanding and possible therapeutic targets for fighting against the COVID-19 infection are discussed.
Highlights
Coronaviruses (CoVs) are the part of the family Coronaviridae with subfamily and order Orthocoronavirinae and Nidovirales (Banerjee et al, 2019)
The WHO (World Health Organization) revealed the outburst of a Public Health Emergency of International Concern (PHEIC) on January 30, 2020. Another name Severe Acute Respiratory Syndrome (SARS)-CoV-2 was suggested by a study group of the International Committee on Taxonomy of Viruses (ICTV) based on taxonomy phylogeny, and established practice on February 11, 2020, afterwards this disease was renamed by WHO as COVID-19 on February 12, 2020
This review holistically explains the current research done in response to outbreak of COVID-19 and 2019-nCoV, mainly focusing on the phylogenetic and epidemiological analysis of Pakistani coronavirus
Summary
Coronaviruses (CoVs) are the part of the family Coronaviridae with subfamily and order Orthocoronavirinae and Nidovirales (Banerjee et al, 2019). Successive virus isolations from human patients and their molecular analysis revealed that the disease-causing agent was a novel coronavirus, first named as 2019-nCoV. The WHO (World Health Organization) revealed the outburst of a Public Health Emergency of International Concern (PHEIC) on January 30, 2020. Another name SARS-CoV-2 was suggested by a study group of the International Committee on Taxonomy of Viruses (ICTV) based on taxonomy phylogeny, and established practice on February 11, 2020, afterwards this disease was renamed by WHO as COVID-19 on February 12, 2020. This review is focused on up to date aspects of COVID-19 and epidemiological and phylogenetic analysis of Pakistani n-CoV strain
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