Curative efficacy of safflower yellow sodium chloride in the treatment of acute myocardial infarction and its effects on cardiac function and oxidative stress

Abstract

Objective To investigate the curative efficacy of safflower yellow sodium chloride in the treatment of acute myocardial infarction (AMI) and its effects on cardiac function and oxidative stress. Methods 110 cases of AMI meeting the inclusion criteria were randomly divided into two groups equally.The control group was given conventional drug treatment and percutaneous coronary intervention (PCI), while the observation group was given conventional drug treatment and PCI in combination with safflower yellow sodium chloride.Then, the curative efficacy, indices of cardiac function and oxidative stress were observed and compared. Results The observation group had a total effective rate of 94.5%, which was significantly higher than 81.8% in the control group (χ2=4.94, P=0.026). After the treatment, SV (t=3.23, P=0.002), CO(t=3.82, P=0.000) and LVEF (t=3.14, P=0.002) in the observation group were significantly higher than those in the control group (all P<0.05). As to oxidative stress, in comparison with the control group, SOD (t=8.42, P=0.000) was significantly higher and MDA (t=3.99, P=0.000) was significantly lower in the observation group (all P<0.05). Conclusion Adjuvant treatment of safflower yellow sodium chloride for AMI was effective, which could significantly increase curative efficacy, improve cardiac function and alleviate oxidative stress. Key words: Safflower yellow sodium chloride; Acute myocardial infarction; Cardiac function; Oxidative stress