Effects of hyperbaric oxygen combined with sodium tanshinone II A sulfonate on inflammatory factors and cardiac function in patients with acute myocardial infarction after thrombolysis

Abstract

Objective To investigate the effects of hyperbaric oxygen (HBO) combined with sodium tanshinone IIA sulfonate on inflammatory factors and cardiac function in patients with acute myocardial infarction (AMI) after thrombolysis. Methods Eighty-eight AMI patients admitted to the Department of Cardiology, Longkou People's Hospital from October 2015 to October 2018 were recruited as research subjects and all conformed to the diagnostic criteria of AMI. The patients were randomly divided into the observation group and the control group, each consisting of 44 patients. The control group was treated with sodium tanshinone II A sulfonate on the basis of routine treatment of AMI, while the observation group was treated with HBO in addition to the treatment received by the control group. Both before treatment and 4 and 8 courses of treatment, close observations were made on serum inflammatory factors, i. e. the levels of: high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6); on cardiac function: i. e. the levels of left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV ); on left ventricular remodeling indicators: i. e. left ventricular posterior wall thickness (LVPWT), end-diastolic septal thickness (IVST) and left ventricular myocardial mass index (LVMI). Results After 4 or 8 courses of treatment, the levels of IL-6, TNF-α and hs-CRP in the 2 groups were significantly lowered as compared with those before treatment (P < 0.01), and there was statistical significance when comparisons were made between them (P<0.01). There was also statistical significance when comparisons were made between the observation group and the control group (P<0.05). After 8 courses of treatment, the LVEF levels of the 2 groups obviously elevated as compared with those before treatment, while the levels of LVESV and LVEDV significantly lowered, and statistical significance could be found when comparisons were made between them (P<0.01). There was also statistical significance, as compared with those of the control group after treatment (P<0.05). After 8 courses of treatment, the levels of LVMI in the patients of the 2 groups all elevated significantly, as compared with those before treatment, while the levels of IVST and LVPWT all considerably decreased in both groups, as compared with those before treatment, also with statistical significance (P<0.01). However, there was also statistical significance as compared with those of the control group after treatment (P<0.05). Conclusion HBO combined with sodium tanshinone IIA sulfonate seemed to have high application value in the treatment of AMI. It could decrease the expression level of serum inflammatory factors, improve cardiac function and inhibit left ventricular remodeling. For this reason, it is worth further clinical application. Key words: Hyperbaric oxygen; Sodium tanshinone IIA sulfonate; Acute myocardial infarction; Thrombolysis; Inflammatory factor; Cardiac function; Left ventricular remodeling