Curative effect of teprenone capsule combined with quadruple therapy in the treatment of chronic atrophic gastritis

Abstract

Objective To analyze the curative effect of teprenone capsule combined with quadruple therapy in the treatment of chronic atrophic gastritis. Methods From June 2013 to June 2017, one hundred and fifty patients with chronic atrophic gastritis admitted to the First Hospital of Ninghai County were retrospectively selected.According to different treatment schemes, they were divided into control group and observation group, with 75 patients in each group.The control group was treated with routine quadruple therapy, and the observation group was treated with teprenone capsule combined with quadruple therapy.The effective rate of the two groups was compared. Results The total effective rate of the observation group was 97.33%, which was higher than 85.33% of the control group, the difference between the two groups was statistically significant(χ2=3.197, P<0.05). After treatment, the levels of interleukin-8 and tumor necrosis factor-alpha in the observation group were (7.04±1.03)ng/L, (41.02±1.72)ng/L, respectively, which in the control group were (10.81±1.63)ng/L, (57.35±2.95)ng/L, respectively, the differences between the two groups were statistically significant (t=6.028, 7.281, all P<0.05). The gastric mucosa score and the gastrin concentration in the observation group were (1.13±0.32)points, (8.97±2.33)pmol/L, respectively, which in the control group were (1.82±0.61)points, (5.36±1.52)pmol/L, respectively, the differences between the two groups were statistically significant(t=5.661, 6.024, all P<0.05). Conclusion Teprenone capsule combined with quadruple therapy can improve the clinical efficacy and reduce the degree of inflammation in patients with chronic atrophic gastritis, which is worthy of clinical application. Key words: Gastritis, atrophic; Teprenone; Rabeprazole; Tinidazole; Claricid; Colloidal bismuth pectin; Interleukin-8; Tumor necrosis factor-alpha