Clinical study on self-made Jianpi-Yiqi decoction in the treatment of chronic atrophic gastritis

Abstract

Objective To evaluate the efficacy of self-made Jianpi-Yiqi decoction in the treatment of chronic atrophic gastritis (CAG). Methods A total of 100 patients with CAG who met the inclusion criteria were randomly divided into two groups, 50 in each group. The control group received oral omeprazole enteric-coated capsules and the observation group oral Jianpi-Yiqi decoction. Both groups were treated for 8 weeks. The clinical efficacy, proliferating cell nuclear antigen (PCNA), B cell lymphoma-2 (Bcl-2), TNF-α and PCNA, Bcl-2 mRNA expression were evaluated and compared. Results The total effective rate was 92.0% (46/50) in the observation group and 80.0% (40/50) in the control group. The difference between the two groups was statistically significant (χ2=9.623, P=0.031). The total effective rate of endoscopy was 94.0% (47/50) in the observation group and 74.0% (37/50) in the control group. The difference between the two groups was statistically significant (χ2=11.254, P=0.026). After treatment, the PCNA (4.36 ± 1.95 μg/mg vs. 8.62 ± 2.43 μg/mg, t=8.465), Bcl-2 (3.06 ± 1.63 μg/mg vs. 7.54 ± 1.73 μg/mg, t=9.316), TNF-α (4.13 ± 1.86 μg/mg vs. 7.29 ± 2.14 μg/mg, t=9.473) in the observation group were significantly lower than those in the control group (P<0.05). After treatment, the PCNA (0.053 ± 0.033 vs. 0.074 ± 0.023, t=2.316), Bcl-2 (0.004 ± 0.003 vs. 0.006 ± 0.002, t=5.842) mRNA expression in the observation group were significantly lower than those in the control group (P<0.05). Conclusions The self-made Jianpi-Yiqi decoction can down-regulate the expression of PCNA, Bcl-2 and TNF-α protein and PCNA and Bcl-2 mRNA in gastric mucosa, improve the symptoms of CAG patients and improve clinical efficacy. Key words: Gastritis, atrophic; Jianpi-Yiqi decoction; Proliferating cell nuclear antigen; Bcl-2; Tumor necrosis factor-alpha; Gastroscopy; Gene expression