Correlation of serum cystatin C and N-terminal pro-brain natriuretic peptide with severity of coronary heart disease

Abstract

Objective To investigate the correlation of serum cystatin C(CysC) and N-terminal brain natriuretic peptide (NT-proBNP) levels with severity of coronary heart disease. Methods 240 patients with coronary artery disease were selected.According to coronary angiography, they were divided into four groups: 52 cases of non-CAD group, coronary single vessel disease group (73 cases), 62 cases of double vessel disease, 53 cases of triple vessel disease group.The serum CysC, NT-proBNP levels were determined and compared among the four groups.The relationship between CysC, NT-proBNP levels and severity of coronary artery disease was analyzed. Results The CysC, NT-proBNP levels in the single coronary vessel disease group, double vessel disease group and multivessel disease group were higher than non-CHD group, the differences were statistically significant(t=2.019, 3.870, 7.449, P=0.046, 0.000, 0.000; t=6.068, 15.365, 24.851, P=0.000, 0.000, 0.000); and with the crown pulse lesion count increased, the serum CysC, NT-proBNP levels increased gradually, the differences were statistically significant(t=2.080, 3.070, P=0.039, 0.000; t=10.953, 12.078, P=0.000, 0.000). Coronary artery disease severity was positively correlated with CysC, NT-proBNP levels (r1=0.562, r2=0.503). Conclusion The severity of coronary artery disease is closely related to the levels of CysC, NT-proBNP, which has some predictive value for coronary artery disease, patients with high CysC, NT-proBNP levels should be given high priority. Key words: serum cystatin C (CysC); Natriuretic peptide, brain; Coronary artery disease