Clinical significance of combined detection of D-Dimer, coagulation four indices and hs-CPR level for coronary heart disease

Abstract

Objective To explore the clinical value of combined detection of D-dimer,coagulation four indices and hs-CRP in diagnosis of coronary heart disease (CHD).Methods D-Dimer,coagulation four indices and hsCPR level were detected in 67 patients with CHD[22 stable angina(SA) pectoris patients,20 unstable angina (UA) pectoris patients and 25 acute myocardial infarction (AMI) patients] and 20 healthy people(normol control group).According to the result of coronary arteriongraphy,the patients with CHD were divided into single vessel disease group (n =21),double vessel disease group (n =23) and three vessel disease group (n =23).The levels of plasma D-D,fibrinogen(FIB) and hs-CRP were detected and compared.Results Compared with UA group,SA group,control group respectively,D-D,fibrinogen and hs-CRP level of AMI group had statistical significance (P ＜ 0.01) ;Compared with SA group,control group,D-D,fibrinogen and hs-CRP level of UA group had statistical significance (P ＜ 0.05) ;Compared with control group,hs-CRP level of SA group had statistical significance (P ＜ 0.01).The comparision of PT,APTT and TT level between each two groups,there was no statistical difference (P ＞ 0.05).The levels of plasma DD and FBG in single vessel disease group,double vessel disease group and three vessel disease group were significantly higher than those in NC group(P ＜ 0.05).The levels of plasma DD and FBG in three vessel disease group were significantly higher than those in single vessel disease group and double vessel disease group(P ＜ 0.05).The levels of plasma DD and FBG in double vessel disease group were significantly higher than those in single vessel disease group (P ＜ 0.05).The comparision of PT,APTT and TT level between each two groups,there was no statistical difference (P ＞ 0.05).Conclusion The level of D-D,FIB and hs-CRP have close relationship with the severe degree of CHD and can help clinical doctor to predict the type of CHD. Key words: Coronary Arteriosclerosis ; D-dimer ; Hs-CRP