Correlation between serum angiopoietin-like protein 2 and the severity of coronary artery disease in patients with coronary heart disease

Abstract

Objective To study the correlation between serum angiopoietin-like protein 2(Angptl2)and the severity of coronary artery disease in patients with coronary heart disease (CHD). Methods A total of 200 patients were divided into two groups according to the results of coronary angiography, CHD group(n=120) and control group(n=80). In CHD group, the patients were further divided into three subgroups as single vessel disease group(n=42), double vessel disease group (n=40), multi-vessel disease group(n=38). Body mass index(BMI) was calculated. The levels of Angptl2, fasting blood-glucose, high sensitivity C-reactive protein(hs-CRP), total cholesterol(TC), triglyceride(TG), HDL- cholesterol(HDL-C), LDL-cholesterol(LDL-C) were detected. Results The level of Angptl2 was higher in CHD group than that in control group (2.41 ng/ml vs 0.92 ng/ml, P<0.01). There were significant diference in three subgroups respectively(P<0.05). Pearson correlation analysis showed that the serum Angptl2 level positively correlated with BMI, hs-CRP, TC, LDL-C. The serum Angptl2 level was significantly positively correlated with Gensini score(r=0.36, P<0.05). Logistic regression analysis showed that the levels of Angptl2 was an independent risk factor of Gensini score(OR=2.436, 95%CI 1.762-3.481, P<0.01). Conclusions Angptl2 can predict the severity of coronary artery lesions and has important clinical significance of evaluate the coronary heart disease. Key words: Angiopoietin-like protein 2; Coronary artery disease; Gensini score; Atherosclerosis