Correlation between inducible nitric oxide synthase(iNOS)gene polymorphisms and coronary heart disease in Chinese Han population

Abstract

Objective To explore the association between inducible nitric oxide synthase(iNOS)gene polymorphisms and coronary heart disease(CHD)in Chinese Han population. Methods A case-control study was conformed, included 291 CHD patients and 487 healthy subjects of the age and sex-matched in Chinese Han population.The genotype of rs2779248(C/T)and rs1137933(C/T)were determined by Taqman SNP genotyping assays. Results After adjusted by conventional risk factors, we found that individuals with rs2779248 TT genotype may have higher risk of CHD(OR=2.58, 95%CI: 1.01-6.67)than individuals with CC genotype; while individuals with CT+ TT genotype also have higher risk of CHD than those with CC genotype, the odds ratio was 1.36(95%CI: 1.00-1.85). Individuals with rs2779248 TT genotype had significant higher level of fasting blood glucose than those with rs2779248 CC genotype. Conclusions Our study reveals the polymorphisms of iNOS gene is associated with CHD in Chinese Han population, iNOS gene may increase the incidence of CHD by affecting the formation of coronary atherosclerotic plaque by regulating blood glucose. Key words: Nitric oxide synthase; Coronary artery disease; Polymorphism, single nucleotide; Risk factors