Abstract
Objective To investigate the correlation between inducible nitric oxide synthase (iNOS) gene polymorphism and ischemic stroke in Chinese Han population. Methods Patients with first-ever stroke and the age-and sex-matched healthy controls were enrolled in the study. Taqman probe fluorescence quantitative polymerase chain reaction technique was used to detect the genotype distribution of rs2779248 C/T and rs1137933 C/T polymorphisms. Results A total of 246 patients with ischemic stroke and 246 controls were enrolled. The distribution frequencies of rs2779248 CC, CT and TT genotypes in the patient group were 57.7%, 36.6%, and 5.7%, respectively, and in the control group were 68.7%, 28.0%, and 3.3%, respectively. The T allele frequency of the patient group was significantly higher than that of the control group (24.0% vs. 17.3%; P=0.015). Multivariate logistic regression analysis showed that after adjusting for the risk factors including age, sex, hypertension, and diabetes, the risk of ischemic stroke in the CT+ TT genotype carriers was 1.64 times of the CC genotype carriers (odds ratio 1.64, 95% confidence interval 1.07-2.51; P=0.022). The distribution frequencies of rs1137933 CC, CT and TT in the patient group were 58.1%, 37.8%, and 4.1%, respectively and in the control group were 68.3%, 29.3%, and 2.4%, respectively. The T allele frequency of the patient group was significantly higher than that of the control group (23.0% vs. 17.1%; P=0.013). Multivariate logistic regression analysis showed that after adjusting for traditional risk factors, the risk of ischemic stroke of patients with the TT+ CT genotype carriers was 1.60 times of the CC genotype carriers (odds ratio 1.60, 95% confidence interval 1.05-2.46; P=0.030). Conclusions The rs2779248 C/T and rs1137933 C/T polymorphisms in iNOS gene may be associated with the risk of onset of ischemic stroke in Chinese Han population. Key words: Stroke; Brain Ischemia; Nitric Oxide Synthase Type Ⅱ; Polymorphism, Genetic; Risk Factors
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