Correlation between high sensitive C-reactive protein, lipoprotein(a), blood uric acid and severity of coronary artery disease

Abstract

To discuss the relationship between high sensitive C-reactive protein (hs-CRP), lipoprotein (Lp)(a), blood uric acid (BUA) and severity of coronary artery disease (CHD). A total of 813 cases of suspected or established coronary atherosclerotic heart disease patients were recruited. The patients received selective coronary arteriography and they were divided into normal and CHD groups according to the result of selective coronary arteriography. The dividing mark was coronary artery stenosis more than 50% by selective coronary arteriography. Patients in CHD group were further divided into 1-4 vessel disease. Blood glucose, cholesterol, triglyceride, LDL-ch, hs-CRP and BUA were detected by automatic biochemical analyzer. Among them, 754 cases (CHD group, 92.7%) were confirmed as coronary heart disease while 59 cases (control group, 7.3%) confirmed as non-coronary heart disease. There were significantly difference between two groups (P < 0.05): hs-CRP (7.12 ± 4.48 vs 1.71 ± 1.42) mg/L, Lp(a) (0.45 ± 0.42 vs 0.18 ± 0.03) mmol/L and BUA (402 ± 103 vs 327 ± 88) µmol/L. The levels of hs-CRP, Lp(a) and BUA in different number of diseased coronary vessels significantly differed from each other (P < 0.05). A comparison of 1-vessel disease group versus 4 vessel disease group was as follows: hs-CRP (3.59 ± 2.93 vs 13.11 ± 3.00) mg/L, Lp(a) (0.37 ± 0.25 vs 0.58 ± 0.17) mmol/L and BUA (384 ± 126 vs 444 ± 91) µmol/L. Logistic regression analysis showed that hs-CRP, Lp(a) and BUA were independent risk factors of coronary artery disease. The elevations of hs-CRP, LP(a) and BUA promote the establishment and development of coronary artery disease. A joint detection of hs-CRP, Lp(a) and BUA shows a comparatively great value in evaluating high-risk groups and the patient's condition. And it provides references for an active intervention of clinical coronary heart disease.