Influence of chronic obstructive pulmonary disease on patients with coronary atherosclerotic heart disease

Abstract

Objective To investigate the influence of chronic obstructive pulmonary disease (COPD) on patients with coronary atherosclerotic heart disease (CHD) patients. Methods A total of 121 CHD patients who were admitted to Beijing Tongren Hospital from August 2012 to March 2018, 61 of them accompanied with COPD, were analyzed for cross-sectional analysis. Coronary angiographic data, Gensini score and high sensitive C reactive protein (hs-CRP) level was compared between the two groups. Results The Gensini score of patients with CHD combined with COPD group was significantly higher than that of CHD alone (120.90±90.68 vs. 65.27±50.38, t=4.162, P=0.000). One or more coronary artery with total occlusion or subtotal occlusion was higher in CHD combined with COPD group than that of CHD group (44.3% vs. 21.7%, χ2=6.979, P=0.008). The hs-CRP level in CHD combined with COPD group was higher than that of the CHD group, but the difference was not statistically significant [(6.95±9.52)mg/L vs. (5.03±4.90)mg/L, t=1.392, P=0.166]. Multivariate logistic regression analysis indicated that COPD was an independent risk factor for CHD with one or more coronary artery complete or subtotal occlusion (OR: 2.838, 95%CI: 1.251-6.437, P=0.013). Conclusions Patients with CHD complicated with COPD have a greater degree of coronary artery stenosis. The proportion of one or more complete or subtotal occlusions is higher in CHD with COPD patients. The influence of COPD affecting on CHD may be systemic inflammatory response. Key words: Pulmonary disease, chronic obstructive; Coronary artery disease; Gensini score; High-sensitivity C-reactive protein; Systemic inflammatory response