Abstract
Objective To investigate the correlation between blood pressure rhythm and left ventricular structure and function in elderly hypertensive patients. Methods A total of 147 elderly patients with high blood pressure in the First Hospital of Longyan Affiliated to Fujian Medical University were selected.All the patients received 24h ambulatory blood pressure examination.According to the rhythm of blood pressure, the patients were divided into the dipper blood pressure group, the-non dipper type blood pressure group and the anti-dipper type blood pressure group.All patients were examined by echocardiography. Results According to the results of 24h dynamic blood pressure, the type of dipper blood pressure accounted for 11.56%(17 cases) in 147 elderly patients, non-dipper type blood pressure type accounted for 51.02%(75 cases), and the anti-dipper type of blood pressure type accounted for 37.41%(55 cases). The ventricular septal thickness(IVST), left ventricular diastolic inner diameter(LVEDD), left atrium inner diameter(LAD), left ventricle posterior wall thickness(LVPWT) and left ventricle mass index(LVMI) of the non-dipper blood pressure group were (10.56±1.51)mm, (50.17±4.31)mm, (34.65±5.78)mm, (9.26±0.98)mm, (102.31±23.23)g/m2, respectively.The IVST, LVEDD, LAD, LVPWT and LVMI of the anti-dipper blood pressure group were (10.51±1.86)mm, (50.20±3.66)mm, (36.96±4.22)mm, (9.42±0.99)mm, (110.47±31.96)g/m2, respectively.The IVST, LVEDD, LAD, LVPWT and LVMI of the dipper blood pressure group were (9.53±1.53)mm, (47.59±2.27)mm, (30.47±4.17)mm, (8.88±1.12)mm, (84.98±15.48)g/m2, respectively.The differences of IVST, LVEDD, LAD, LVPWT and LVMI in the three groups were statistically significant(F=1.172, 3.428, 1.006, 0.135, all P 0.05). The average daytime systolic pressure in the dipper blood pressure group was (143.06±13.70)mmHg, which was higher than that in the non-dipper blood pressure group[(133.25±13.28)mmHg] and anti-dipper blood pressure group[(131.16±12.26)mmHg], the differences were statistically significant(t=-2.734, -3.401, all P<0.05). The mean evening systolic pressure and the average nocturnal diastolic pressure of anti-dipper blood pressure group were (139.04±15.01)mmHg and (80.18±10.29)mmHg, respectively, which were higher than those of the dipper and non-dipper blood pressure group [(123.24±14.49)mmHg and (72.24±7.97)mmHg, (127.40±13.30)mmHg, (73.45±11.43)mmHg], the differences were statistically significant(t=3.822, 4.666, 2.919, 3.456, all P<0.05). LVMI was positively correlated with age, body mass index(BMI), low density lipoprotein(LDL-C), daytime average systolic pressure, night average systolic pressure, night average diastolic pressure, and 24h average systolic pressure(r=0.256, 0.241, 0.687, 0.251, 0.380, 0.203, 0.243, all P<0.05). Conclusion Anti-dipper blood pressure and non-dipper blood pressure have more significant damage to cardiac function and structure than dipper blood pressure in elderly patients with hypertension, and the elevation of nocturnal blood pressure is closely related to left heart structure and function damage.There is a high correlation between abnormal circadian rhythm of blood pressure and left ventricular hypertrophy in elderly hypertensive patients. Key words: Hypertension; Blood pressure; Circadian rhythm; Blood pressure monitoring, ambulatory; Echocardiography; Ventricular function, left; Cardiomegaly; Aged
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