Correlation analysis of serum homocysteine and cerebral artery stenosis in cerebral infarction patients

Abstract

Objective To analyze the relationship between the level of serum homocysteine and cerebral artery stenosis in cerebral infarction patients. Methods Clinical data from 165 cerebral infarction patients who had been done cerebral angiography examination were analyzed.According to the level of serum homocysteine,the patients were divided into 5.0-15.0μmol/L group,15.1-20.0μmol/L group and above 20.1μmol/L group.Other risk factors including age,gender,blood pressure,blood lipid and blood glucose were recorded.The number of cerebral vascular stenosis in different parts of brain were analyzed,and then make a decision of the relationship between the level of serum homocysteine and cerebral artery stenosis,as well as the other risk factors. Results Among 165 cases,74 cases(48.15%) came from 5.0-15.0μmol/L group and the number of stenosal cerebral vascular was 36strips,50 cases(30.12%)came from 15.0-20.0μmol/L group and the number of stenosal cerebral vascular was 66 strips,41 cases(24.70%) came from above 20.1μmol/L group and the number of stenosal cerebral vascular was 67.Analysis of variance was conducted between the numbers of stenosal cerebral vascular of each group,the differences were significant(F= 4.12,P<0. 05). Conclusion In cerebral infarction patients,the incidence of Hcy(hyperhomocysteinemia) was higher than that of normal hcy.2.shows more serious damage of intracranial and extracranial arterial sclerosis occur in patients with the increase of homocysteine levels. Key words: Cerebral infarction; Homocysteine; Cerebral artery stenosis; Risk factors