Abstract
ABSTRACTLiver cancer remains one of the most lethal malignancies worldwide. We sequenced the complete mitochondrial genome of a liver cancer HA22T cell line. The sequenced mitogenome of 16,603 bp will aid in the use of the HA22T cell line for liver cancer study.
Highlights
Liver cancer remains one of the most lethal malignancies worldwide
We report the complete mitochondrial genome sequence of the liver cancer HA22T cell line
With the exception of ND2, ND3, and ND5 that use the start codon ATA and ND4L that uses GTG, the other protein-coding genes use ATG as the start codon. When it came to stop codons, six genes terminated with TAA, whereas ND1 and ND2 terminated with TAG and Cytb terminated with AGA
Summary
Liver cancer remains one of the most lethal malignancies worldwide. We sequenced the complete mitochondrial genome of a liver cancer HA22T cell line. Mitochondrial DNA (mtDNA) is a closed double-stranded circular molecule that typically contains 37 genes, including two rRNAs and 22 tRNAs [2]. Previous studies [2, 3] have suggested that mitochondrial DNA instability and variation are associated with many diseases in both animals and humans. Sequencing the complete mitochondrial DNA sequence would aid in the clinical study of the disease and therapy.
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