Abstract
Escherichia coli represents the primary etiological agent responsible for urinary tract infections, one of the most common infections in humans. We report here the complete genome sequence of uropathogenic Escherichia coli strain CI5, a clinical pyelonephritis isolate used for studying pathogenesis.
Highlights
Escherichia coli represents the primary etiological agent responsible for urinary tract infections, one of the most common infections in humans
Studies of uropathogenic Escherichia coli (UPEC) pathogenesis have revealed that intracellular infection of bladder epithelial cells is a key feature leading to bacterial survival, antibiotic resistance, and recurrent Urinary tract infections (UTIs) [5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20]
UPEC strain CI5 is a clinical pyelonephritis isolate [21] that has been used in many of these studies using both in vitro cell culture models and in vivo murine infection models [22, 23]. These have examined the role of Toll-like receptor 4 (TLR4) [13], cyclic AMP, and Ca2ϩ signaling during UPEC invasion into bladder epithelial cells and the subsequent epithelial cell response [12, 16, 24]
Summary
Escherichia coli represents the primary etiological agent responsible for urinary tract infections, one of the most common infections in humans. Urinary tract infections (UTIs) are one of the most frequently encountered bacterial infections, with uropathogenic Escherichia coli (UPEC) responsible for more than 80% of community acquired infections [1]. Often characterized as selflimiting and amenable to antibiotic therapy, UTIs often recur, causing significant morbidity to individual patients [2].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
