Abstract
A novel flavi-like virus tentatively named Diaphorina citri flavi-like virus (DcFLV) was identified in field populations of Diaphorina citri through small RNA and transcriptome sequencing followed by reverse transcription (RT)-PCR. We report here the complete nucleotide sequence and genome organization of DcFLV, the largest flavi-like virus identified to date.
Highlights
The flavi-like viruses are a group of viruses which share genome organization and encoded proteins with viruses of the family Flaviviridae [1]
The open reading frame (ORF) is translated into a single polyprotein which is subsequently cleaved into structural (CP and envelope) and nonstructural proteins located at the N- and C-termini, respectively [1]
The phylogenetic status of flavi-like viruses is not clear, they fall among flavivirus-jingmenvirus, pestivirus, and hepacipegivirus clades based on amino acid sequences of the NS3 and NS5 (RdRp) proteins [4]
Summary
The flavi-like viruses are a group of viruses which share genome organization and encoded proteins with viruses of the family Flaviviridae [1]. The typical Flavivirus genome is a positive-sense, singlestranded unsegmented RNA 9.6 to 12.3 kb in length containing a single open reading frame (ORF) [1]. Unlike the typical Flavivirus, the genomes of flavi-like viruses have been reported to be between 19 and 26 kb [2,3,4,5,6].
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