Abstract
Sequencing of the blaKPC-positive strain Proteus mirabilis AOUC-001 was performed using both the MiSeq and PacBio RS II platforms and yielded a single molecule of 4,272,433 bp, representing the complete chromosome. Genome analysis showed the presence of several acquired resistance determinants, including two copies of blaKPC-2 carried on a fragment of a KPC-producing plasmid previously described in Klebsiella pneumoniae.
Highlights
Sequencing of the blaKPC-positive strain Proteus mirabilis AOUC-001 was performed using both the MiSeq and PacBio RS II platforms and yielded a single molecule of 4,272,433 bp, representing the complete chromosome
P. mirabilis AOUC-001 was isolated in 2013 from the blood culture from an inpatient admitted to the Santa Maria Annunziata Hospital (Florence, Italy)
A total of 3,853 coding sequences, 83 tRNAs, 22 rRNAs, and 1 type-IE clustered regularly interspaced short palindromic repeat (CRISPR)-associated (Cas) system were identified by the NCBI Prokaryotic Genome Annotation Pipeline
Summary
Sequencing of the blaKPC-positive strain Proteus mirabilis AOUC-001 was performed using both the MiSeq and PacBio RS II platforms and yielded a single molecule of 4,272,433 bp, representing the complete chromosome. Proteus mirabilis is one of the leading agents of urinary tract infections and can cause a number of different health careassociated infections, including mainly respiratory tract and skin infections, and bacteremia [1]. The acquisition of blaKPC by P. mirabilis represents a rare event, and only a few descriptions have been reported to date [7,8,9].
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