Abstract
Streptococcus iniae ISNO is an attenuated novobiocin-resistant vaccine strain. Its full genome is 2,070,182 bp in length. The availability of this genome will allow comparative genomics to identify potential virulence genes important for pathogenesis of S. iniae and potential mechanisms associated with novobiocin resistance in this strain.
Highlights
Streptococcus iniae ISNO is an attenuated novobiocin-resistant vaccine strain
The vaccine strain S. iniae ISNO was found to be totally safe to Nile tilapia at various exposure doses and in back passage safety studies [13]
Compared to the virulent parent S. iniae ISET0901, the vaccine strain S. iniae ISNO was ~1,000-fold resistant to novobiocin
Summary
Streptococcus iniae ISNO is an attenuated novobiocin-resistant vaccine strain. Its full genome is 2,070,182 bp in length. As a serious marine and freshwater fish pathogen, S. iniae causes significant economic losses to aquaculture [4, 5]. A highly virulent strain, S. iniae ISET0901, was cultured from diseased Nile tilapia (Oreochromis niloticus) during a disease outbreak in 2005 [13].
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