Abstract
We present here the genome sequence of the attenuated Corynebacterium pseudotuberculosis strain T1. The sequencing was performed with an Ion Torrent Personal Genome Machine platform. The genome is a circular chromosome of 2,337,201 bp, with a G+C content of 52.85% and a total of 2,125 coding sequences (CDSs), 12 rRNAs, 49 tRNAs, and 24 pseudogenes.
Highlights
Corynebacterium pseudotuberculosis is the etiologic agent of caseous lymphadenitis, a chronic disease that affects small ruminants worldwide
We present the complete genome sequence of C. pseudotuberculosis strain T1. This strain was isolated from a goat lymph node in Bahia State, Brazil, and belongs to C. pseudotuberculosis bv. ovis; after several passages in culture, it was considered to present low virulence and was used as an attenuated immunogen in goats, producing 33.3% protection against caseous lymphadenitis clinical signs (2)
It was described that the secreted/excreted antigens of the T1 strain showed 89% sensitivity and 99% specificity in the detection of specific anti-C. pseudotuberculosis IgG antibodies in sheep (1)
Summary
Corynebacterium pseudotuberculosis is the etiologic agent of caseous lymphadenitis, a chronic disease that affects small ruminants worldwide. We present the complete genome sequence of C. pseudotuberculosis strain T1. This strain was isolated from a goat lymph node in Bahia State, Brazil, and belongs to C. pseudotuberculosis bv. It was described that the secreted/excreted antigens of the T1 strain showed 89% sensitivity and 99% specificity in the detection of specific anti-C. pseudotuberculosis IgG antibodies in sheep (1).
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