Abstract
The complete genome sequence of a novel pseudorabies virus, strain HNB, isolated from a dead weaned pig in China, was determined using next-generation sequencing. The viral genome sequence of HNB shared 90.6% nucleotide similarity with that of the traditional vaccine strain, the Bartha strain.
Highlights
The complete genome sequence of a novel pseudorabies virus, strain HNB, isolated from a dead weaned pig in China, was determined using next-generation sequencing
Pseudorabies virus (PRV) is an enveloped double-stranded DNA virus that belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus, with a genome size of approximately 140 kb [1]
The attenuated Bartha-K61 based vaccine and other live or killed vaccines have widely been used in China since the 1970s, and the eradication program is being conducted, porcine PR is well controlled worldwide including in China [5]
Summary
The complete genome sequence of a novel pseudorabies virus, strain HNB, isolated from a dead weaned pig in China, was determined using next-generation sequencing. Pseudorabies virus (PRV) is an enveloped double-stranded DNA virus that belongs to the family Herpesviridae, subfamily Alphaherpesvirinae, genus Varicellovirus, with a genome size of approximately 140 kb [1]. The viral genome is similar to those of other alphaherpesviruses, consisting of a unique long (UL) region, internal repeat sequences (IRS), a unique short (US) region, and terminal repeat sequences (TRS) [2]. PRV is the causative agent of Aujeszky’s disease or pseudorabies (PR) in pigs [3].
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