Abstract
Mycobacterium chimaera is a nontuberculous mycobacterial species that causes cardiovascular, pulmonary, and postsurgical infections. Here, we report the first complete genome sequence of M. chimaera. This genome is 6.33 Mbp, with a G+C content of 67.56%, and encodes 4,926 protein-coding genes, as well as 74 tRNAs, one ncRNA, and three rRNA genes.
Highlights
Mycobacterium chimaera is a nontuberculous mycobacterial species that causes cardiovascular, pulmonary, and postsurgical infections
The assembly was compared to other Mycobacterium avium complex (MAC) genomes using Mauve version 2.3.1 [9]
The genome of M. chimaera AH16 consists of 4 scaffolds equaling 6,328,534 bp (5,851,561-bp chromosome; 437,456-bp plasmid; 25,007-bp plasmid; 14,510-bp plasmid) and a GϩC content of 67.56%
Summary
Mycobacterium chimaera is a nontuberculous mycobacterial species that causes cardiovascular, pulmonary, and postsurgical infections. Mycobacterium chimaera is a nontuberculous mycobacterial species within the Mycobacterium avium complex (MAC). The use of single genes such as the 16s rRNA or rpoB for species identification often misidentifies M. chimaera as the closely related MAC species M. intracellulare [1, 2]. In health-care settings, the occurrence and spread of M. chimaera infections have increased in prevalence in recent years, including recent outbreaks that have been attributed to contaminated medical equipment [4,5,6].
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