Abstract
ABSTRACTHuman coronavirus strain 229E (HCoV-229E) and human alphaherpesvirus 1 were isolated from the plasma of a Haitian child in 2016 with suspected arbovirus diseases. To our knowledge, this is the first description of HCoV-229E in human plasma, which is the focus of this article.
Highlights
Human coronavirus strain 229E (HCoV-229E), one of the causative agents of the common cold, is increasingly associated with more severe respiratory infections in children, elders, and individuals with underlying medical conditions [1,2,3,4]
The study protocol was approved by the University of Florida Institutional Review Board (IRB) and the Haitian National IRB, with written consent obtained from parents/guardians of all study participants
HCoV-229E viral genomic RNA was detected using a GenMark multiplex PCR eSensor XT-8 respiratory viral panel, and its identity was supported by the generation of correct-sized PCR amplicons using RT-PCR assays targeting HCoV-229E-specific genes [12,13,14]
Summary
Human coronavirus strain 229E (HCoV-229E), one of the causative agents of the common cold, is increasingly associated with more severe respiratory infections in children, elders, and individuals with underlying medical conditions [1,2,3,4]. During a suspected arbovirus outbreak in March 2016, HCoV-229E and human alphaherpesvirus 1 (information to be presented elsewhere) were isolated from the plasma of a child presenting with acute undifferentiated febrile illness at a school clinic in rural Haiti. The study protocol was approved by the University of Florida Institutional Review Board (IRB) and the Haitian National IRB, with written consent obtained from parents/guardians of all study participants.
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