Abstract
We report here the complete genome sequence of Ehrlichia muris strain AS145T, which was isolated from a wild mouse in 1983 in Japan. E. muris establishes persistent infections in laboratory mice and is widely used as a surrogate pathogen in a murine model of ehrlichiosis.
Highlights
Ehrlichia are tick-borne Gram-negative bacterial pathogens that belong to the family Anaplasmataceae within the order Rickettsiales and the class Alphaproteobacteria
E. muris was first isolated from the spleen of a wild mouse (Eothenomys kageus) in in 1983 in Japan [10, 11]
The strain has been maintained in the laboratory by continuous passage in a DH82 canine monocytic cell line
Summary
Human ehrlichial pathogens include Ehrlichia chaffeensis, Ehrlichia ewingii, and a recently discovered new species, Ehrlichia muris-like agent (EMLA) [1,2,3]. Ehrlichia canis and Ehrlichia ruminantium cause disease in canines and ruminants, respectively [4]. E. chaffeensis and E. ewingii cause disease in dogs. E. chaffeensis and E. ewingii do not cause disease in immunocompetent mice; surrogate murine pathogens E. muris and Ixodes ovatus ehrlichia (IOE) are used in animal models of ehrlichiosis [5, 6].
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