Abstract
In 2007, clusters of severe coxsackievirus B1 (CVB1) infection occurred across the United States, and CVB1 became the most commonly reported enterovirus. The complete genome sequence of CVB1 isolated from an infant (CVB1-Chi07) was examined and found to be divergent from the Conn5 reference strain, with 80% and 96% similarities at the nucleotide and amino acid levels, respectively.
Highlights
Coxsackievirus B1 (CVB1) belongs to the Enterovirus B species
CVB1 was first recognized in 1948 (CVB1-Conn5 strain) and was sporadically identified as one of the top five enteroviruses circulating in the United States in 1977, 1991, and 1992 [1]
CVB1-Chi07 was originally obtained from Stanford Shulman at Northwestern University and propagated in HeLa-RW cells [7]
Summary
Coxsackievirus B1 (CVB1) belongs to the Enterovirus B species (within the genus Enterovirus, family Picornaviridae). CVB1 was first recognized in 1948 (CVB1-Conn5 strain) and was sporadically identified as one of the top five enteroviruses circulating in the United States in 1977, 1991, and 1992 [1]. In 2007, it reemerged with nationwide clusters of cases and became the most commonly isolated enterovirus in the United States [2].
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