Abstract
Papillomaviruses are epitheliotropic, circular, double-stranded DNA viruses within the family Papillomaviridae that are associated with benign and malignant tumors in humans and animals. We report the complete genome sequence of canine papillomavirus type 16 identified within multiple pigmented cutaneous plaques and squamous cell carcinoma from an intact female Basenji dog.
Highlights
Papillomaviruses are epitheliotropic, circular, double-stranded DNA viruses within the family Papillomaviridae that are associated with benign and malignant tumors in humans and animals
This report describes the complete viral genome of a novel canine papillomavirus type, designated canine papillomavirus type 16 (CPV-16), identified from pigmented cutaneous plaques that progressed to squamous cell carcinoma in a female Basenji dog
Total viral DNA was isolated from both pigmented plaques and samples of squamous cell carcinoma by routine methods
Summary
Papillomaviruses are epitheliotropic, circular, double-stranded DNA viruses within the family Papillomaviridae that are associated with benign and malignant tumors in humans and animals. Papillomaviruses (PVs) are circular double-stranded DNA viruses associated with both benign and malignant epithelial proliferations [1]. Cutaneous PV infections typically regress spontaneously; there are rare cases of malignant transformation to in situ or invasive squamous cell carcinoma [2,3,4]. Identification and sequence analysis of specific PV types associated with a more malignant behavior is valuable for studies on viral oncogenesis and the host immune response to PV infections [4,5,6,7].
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