Abstract
The complete genome sequence of the genotype 3 border disease virus strain Gifhorn has been determined; this strain was originally isolated from pigs. This represents the consensus sequence for the virus used to produce the bacterial artificial chromosome (BAC) cDNA clone pBeloGif3, which yields a virus that is severely attenuated in cell culture.
Highlights
The complete genome sequence of the genotype 3 border disease virus strain Gifhorn has been determined; this strain was originally isolated from pigs
Border disease virus (BDV) causes disease mainly in small ruminants, but cattle, pigs, and other wildlife may be infected; the BDV genotype 3 (BDV-3) strain Gifhorn was originally isolated from both infected pigs and sheep kept on the same farm (1, 2)
A complete sequence for BDV-3 Gifhorn was published previously, but this was derived from a bacterial artificial chromosome (BAC) cDNA clone, pBeloGif3
Summary
The complete genome sequence of the genotype 3 border disease virus strain Gifhorn has been determined; this strain was originally isolated from pigs. BDV causes disease mainly in small ruminants, but cattle, pigs, and other wildlife may be infected; the BDV genotype 3 (BDV-3) strain Gifhorn was originally isolated from both infected pigs and sheep kept on the same farm (1, 2). The BDV genome consists of a positive-sense RNA approximately 12.3 kb in length, which encodes a single polyprotein that is posttranslationally cleaved to form structural and nonstructural proteins. Complete genomic sequences have been described for genotypes BDV-1 (strains BD31 [4] and X818 [5]), BDV-2 (strain Reindeer-1 [6]), and BDV-4 (strain H2121 [3]).
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