Abstract
Streptococcus oligofermentans, an oral commensal, inhibits the growth of the dental caries pathogen Streptococcus mutans by producing large amounts of hydrogen peroxide. Therefore, it can be a potential probiotic for oral health. Here we report the complete genome sequence of S. oligofermentans strain AS 1.3089.
Highlights
Streptococcus oligofermentans, an oral commensal, inhibits the growth of the dental caries pathogen Streptococcus mutans by producing large amounts of hydrogen peroxide
It has been demonstrated that S. oligofermentans possesses multiple H2O2-generating enzymes, including lactate oxidase (Lox) [3], pyruvate oxidase [4], and L-amino acid oxidase (L-AAO) [5, 6]
S. oligofermentans utilizes Lox to convert the abundant lactate produced by S. mutans into H2O2, which inhibits the growth of S. mutans [3]
Summary
Streptococcus oligofermentans, an oral commensal, inhibits the growth of the dental caries pathogen Streptococcus mutans by producing large amounts of hydrogen peroxide. Streptococcus oligofermentans was first described in 2003 [1]. S. oligofermentans produces large amounts of hydrogen peroxide (H2O2), it tolerates high concentrations of H2O2; these characteristics enable it to outcompete the dental caries pathogen Streptococcus mutans in a two-species biofilm model [3]. It has been demonstrated that S. oligofermentans possesses multiple H2O2-generating enzymes, including lactate oxidase (Lox) [3], pyruvate oxidase [4], and L-amino acid oxidase (L-AAO) [5, 6].
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