Abstract
Pseudorabies virus (PRV) variants have been prevalent in China since 2011 and have caused huge economic losses to the Chinese pig industry. Here, we report the genome sequence of a PRV variant HN1201 that was isolated from diseased animals in central China in 2011.
Highlights
Pseudorabies virus (PRV) variants have been prevalent in China since 2011 and have caused huge economic losses to the Chinese pig industry
The HN1201 genome includes 69 open reading frames (ORFs), and some ORFs show extensive variations compared with previously isolated PRV strains
The most variant genetic changes of HN1201 are located in the glycoproteins, including glycoprotein B, C, E, and I, which play important roles in virus entry, egress, cell-to-cell spread, and modulation of immune responses [5]
Summary
Pseudorabies virus (PRV) variants have been prevalent in China since 2011 and have caused huge economic losses to the Chinese pig industry. Pseudorabies virus (PRV) is a double strand DNA virus of the genus Varicellovirus, subfamily Alphahepersvirinae, and family Herpesviridae, which causes pseudorabies (PR), or Aujeszkys’ disease, in livestock and wild animals [1]. PR has been effectively controlled by using attenuated live or inactivated vaccines in China since the 1970s. Highly pathogenic PRV variants with clinical manifestations of high fever, depression, anorexia, cough, shivering, diarrhea, and systemic neurological symptoms with high mortality started to emerge and became prevalent in Bartha-K61 vaccinated pig herds in late 2011 [2, 3].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
