Abstract
ABSTRACTThe incidence of scarlet fever cases remains high in China. Here, we report the complete genome sequence of a Streptococcus pyogenes isolate of serotype M12, which has been confirmed as the predominant serotype in recent outbreaks. Genome sequencing was achieved by a combination of Oxford Nanopore MinION and Illumina methodologies.
Highlights
The incidence of scarlet fever cases remains high in China
De novo assembly in combination with the Illumina short reads and Oxford Nanopore Technologies (ONT) long reads generated a single contig with a length of 1,939,733 bp and a GϩC content of 38.5%
Genome sequence alignment shows that TJ11-001 harbors four mobile genetic elements, including HKU.ssa and ICE-HKU937, which may both play an important role in the clonal expansion of M12 group A Streptococcus (GAS) species, which cause scarlet fever
Summary
The incidence of scarlet fever cases remains high in China. Here, we report the complete genome sequence of a Streptococcus pyogenes isolate of serotype M12, which has been confirmed as the predominant serotype in recent outbreaks. Illumina sequencing generated 2,679,224 reads and 335 Mb of high-quality raw data. De novo assembly generated 25 contigs of 1,904,680 bp length.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
