Abstract
ABSTRACTThe incidence of scarlet fever cases remains high in China. Here, we report the complete genome sequence of a Streptococcus pyogenes isolate of serotype M12, which has been confirmed as the predominant serotype in recent outbreaks. Genome sequencing was achieved by a combination of Oxford Nanopore MinION and Illumina methodologies.
Highlights
The incidence of scarlet fever cases remains high in China
De novo assembly in combination with the Illumina short reads and Oxford Nanopore Technologies (ONT) long reads generated a single contig with a length of 1,939,733 bp and a GϩC content of 38.5%
Genome sequence alignment shows that TJ11-001 harbors four mobile genetic elements, including HKU.ssa and ICE-HKU937, which may both play an important role in the clonal expansion of M12 group A Streptococcus (GAS) species, which cause scarlet fever
Summary
The incidence of scarlet fever cases remains high in China. Here, we report the complete genome sequence of a Streptococcus pyogenes isolate of serotype M12, which has been confirmed as the predominant serotype in recent outbreaks. Illumina sequencing generated 2,679,224 reads and 335 Mb of high-quality raw data. De novo assembly generated 25 contigs of 1,904,680 bp length.
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