Abstract
ABSTRACTIn 2015, a female patient returning to Australia from Sabah, Malaysia, was diagnosed with a suspected sylvatic dengue virus type 2 (DENV-2) infection, becoming the second case of imported highly divergent dengue virus infection recorded in Australia. We describe here the complete genome sequencing of the DENV-2 strain isolated from this patient.
Highlights
In 2015, a female patient returning to Australia from Sabah, Malaysia, was diagnosed with a suspected sylvatic dengue virus type 2 (DENV-2) infection, becoming the second case of imported highly divergent dengue virus infection recorded in Australia
In 2014, we isolated a highly divergent DENV-1 of likely sylvatic origin from a traveler returning from Brunei, Borneo, to Brisbane, Queensland, Australia [6]
In 2015, we diagnosed the second Australian case of highly divergent DENV infection in a febrile female patient who had returned to Brisbane from Sabah, Malaysia, and were the first to report the discovery and isolation of the most divergent DENV-2 strain yet reported (D2Sab2015) [13]
Summary
In 2015, a female patient returning to Australia from Sabah, Malaysia, was diagnosed with a suspected sylvatic dengue virus type 2 (DENV-2) infection, becoming the second case of imported highly divergent dengue virus infection recorded in Australia. The transmission of DENV involves both endemic/epidemic cycles between humans and A. aegypti or A. albopictus mosquitoes and sylvatic cycles between arboreal Aedes mosquitoes and nonhuman primates. While most human infections result from endemic/epidemic DENV transmission, spillover and infection of humans with sylvatic DENVs can occur.
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