Abstract
We determined the complete genome sequence of a coxsackievirus A16 strain (CVA16/SZ29/CHN/2014) from a fatal case in Shenzhen, southern China, in 2014. The strain was assigned to subgenotype B1b based on phylogenetic analysis of the VP1 gene.
Highlights
We determined the complete genome sequence of a coxsackievirus A16 strain (CVA16/SZ29/CHN/2014) from a fatal case in Shenzhen, southern China, in 2014
Enteroviruses are a group of naked, positive, singlestranded RNA viruses, and their genomes consist of a 5= untranslated region (UTR), a structural polypeptide P1, nonstructural polypeptides P2 and P3, and a 3= UTR [2]
The fecal specimen from this case was detected positive for Coxsackievirus A16 (CVA16) by real-time reverse transcription (RT)-PCR and propagated in rhabdomyosarcoma (RD) cell lines at the Department of Microbiology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China
Summary
We determined the complete genome sequence of a coxsackievirus A16 strain (CVA16/SZ29/CHN/2014) from a fatal case in Shenzhen, southern China, in 2014. Coxsackievirus A16 (CVA16), a member of the enterovirus A species of the family Picornaviridae, is a common causative agent of hand, foot, and mouth disease (HFMD) in children and infants [1]. Enteroviruses are a group of naked, positive, singlestranded RNA viruses, and their genomes consist of a 5= untranslated region (UTR), a structural polypeptide P1, nonstructural polypeptides P2 and P3, and a 3= UTR [2]. CVA16 can be phylogenetically classified into two main genogroups (A and B) and five genotypes (A, B1a to B1c, and B2) based on VP1 genes [3].
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