Abstract
We obtained the complete coding genome of an eastern equine encephalitis virus (EEEV) strain, EEEV V105-00210, and the complete genome of a Venezuelan equine encephalitis virus (VEEV) strain, VEEV INH-9813. They were obtained from human cases and are proposed as reference challenge strains for vaccine and therapeutic development in animal models.
Highlights
Venezuelan equine encephalitis (VEEV) and eastern equine encephalitis (EEEV) viruses belong to the Alphavirus genus within the Togaviridae family
equine encephalitis virus (EEEV) isolates from South America are avirulent to humans, North American isolates are highly virulent, being the most deadly mosquito-borne pathogen in North America [4], with a fatality rate estimated at 35 to 75% [5]
To facilitate vaccine and drug research efforts [12,13,14,15], we provide the viral genome sequences of the two challenge stocks derived from the two human isolates
Summary
Venezuelan equine encephalitis (VEEV) and eastern equine encephalitis (EEEV) viruses belong to the Alphavirus genus within the Togaviridae family. They are positive-strand RNA viruses causing fatal encephalitis in horses and humans. VEEV has mainly been found in South and Central America, causing extensive epizootic infections in horses and widespread epidemic infections in humans [1, 2].
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