Comparison of the efficacy and safety of different synchronization chemotherapy for middle-advanced cervical cancer

Abstract

Objective To explore the efficacy and safety of different synchronization chemotherapy for middle -advanced cervical cancer. Methods 96 patients with middle-advanced cervical cancer were selected as the research objects.According to the digital table,they were divided into the observation group and control group, 48 cases in each group.The observation group was used radiotherapy combined with nedaplatin chemotherapy, The control group was used radiotherapy cisplatin and 5-fluorouracil chemotherapy,The efficacy,transfer rate,pelvic recurrence rate,4 year survival rate and side effect of the two groups were compared. Results The effective rate in the observation group was 91.8%,87.5%in the control group,there was no significant difference between the two groups(χ2=0.446 5,P>0.05);The rate of distant metastasis,pelvic recurrence and 4 year survival rates between the two groups had no significant difference(χ2=1.200 0,1.338 0,1.523 8,all P>0.05); The incidence rate ofⅢneutropenia in the observation group was 4.2%,which was lower than 22.9%in the control group(χ2=7.206 7,P<0.05);The incidence rateⅢgastrointestinal reaction of the observation group was 20.8%,which was lower than 47.9%of the control group(χ2=7.803 8,P<0.05). Conclusion The two schemes of radiotherapy clinical curative effect of chemotherapy in the treatment of middle-advanced cervical cancer has a same effect,and the patients of nedaplatin chemoradiotherapy has better tolerability,safety,which is worth of clinical application. Key words: Uterine Cervical Neoplasms; Uterine Neoplasms; Radiotherapy; Chemotherapy,Adjuvant