Clinical efficacy of preoperative radiotherapy and chemotherapy in 39 patients with locally advanced cervical cancer

Abstract

Objective To analyze the clinical efficacy of preoperative concurrent radiotherapy and chemotherapy and radical operation in the treatment of cervical cancer patients with locally advanced cervical cancer (IB-IIB). Methods 80 patients who were diagnosed locally advanced (stage IB-IIB) cervical cancer, were divided into observation group (preoperative radiotherapy and chemotherapy group) and control group (radical radiotherapy group). The short-term efficacy, complications and follow-up data were compared between the two groups. Results The short-term efficacy of the observation group was 87.2%, which of the control group was 95.1%, and there was no significant difference (χ2=1.579, P=0.209). As to the early complications of the two groups, there were no significant differences in gastrointestinal tract reaction(χ2=0.000, P=0.987), rectal reaction(χ2=2.709, P=0.100), bladder reaction (χ2=1.343, P=0.247) and bone marrow suppression(χ2=1.898, P=0.168). Late complications: in the observation group, the radiation proctitis[4 cases(10.3%) vs.14 cases(34.1%)]and the radiation cystitis[3 cases(7.7%) vs.13 cases(31.7%)] were less than those of the control group, the differences were statistically significant(χ2=6.542, P=0.011&χ2=7.205, P=0.007). The average follow-up time was 38.6 months in the observation group, which was 44.8 months in the control group.There was no significant difference in survival rate between the two groups(χ2=0.075, P=0.784 & χ2=0.032, P=0.858). Conclusion Locally advanced cervical cancer (IB-IIB) patients received preoperative concurrent radiotherapy and chemotherapy has important clinical value.The treatment makes the local giant block tumor shrink significantly, which is conducive to the implementation of surgery, and reduce the incidence of late complications compared with radical radiotherapy. Key words: Cervical neoplasms; Locally advanced; Radiotherapy; Chemotherapy