Abstract
Objective To observe the effects of rosuvastatin and atorvastatin on vascular endothelial and car -diac function of patients with early acute myocardial infarction .Methods 162 patients with early acute myocardial infarction were selected and randomly divided into A group and B group by the digital table ,81 cases in each group . The two groups were given conventional treatment of myocardial infarction ,and A group was given rosuvastatin 10mg/d, and B group received atorvastatin 20mg/d,all the patients were treated for 6 months.Results After 6 months of treatment,the total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C),hs-CRP in two groups were significantly reduced,FMD,serum NO were increased,the differences were statistically significant (t=2.573,2.487, 2.422,2.556,3.223,3.175,2.583,2.542,3.528,3.107,3.506,2.982,all P〈0.05).TC,LDL-C and hs-CRP in A group were significantly lower than those in B group (t=2.327,2.228,2.328,all P〈0.05).Conclusion Rosuv-astatin and atorvastatin can reduce blood lipids in patients with premature coronary heart disease and acute myocardial infarction,reduce inflammation and improve endothelial function ,they have similar short-term efficacy,but rosuvastatin has stronger lipid-lowering effect and reducing inflammatory function . Key words: Coronary artery disease; Rosuvastatin ; Atorvastatin ; Endothelium, vascular; Heart function tests
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