Comparison of the effect of rosuvastatin and atorvastatin on vascular endothelial and cardiac function of patients with early acute myocardial infarction

Abstract

Objective To observe the effects of rosuvastatin and atorvastatin on vascular endothelial and car -diac function of patients with early acute myocardial infarction .Methods 162 patients with early acute myocardial infarction were selected and randomly divided into A group and B group by the digital table ,81 cases in each group . The two groups were given conventional treatment of myocardial infarction ,and A group was given rosuvastatin 10mg/d, and B group received atorvastatin 20mg/d,all the patients were treated for 6 months.Results After 6 months of treatment,the total cholesterol（TC）,triglyceride（TG）,low density lipoprotein（LDL-C）,hs-CRP in two groups were significantly reduced,FMD,serum NO were increased,the differences were statistically significant （t=2.573,2.487, 2.422,2.556,3.223,3.175,2.583,2.542,3.528,3.107,3.506,2.982,all P〈0.05）.TC,LDL-C and hs-CRP in A group were significantly lower than those in B group （t=2.327,2.228,2.328,all P〈0.05）.Conclusion Rosuv-astatin and atorvastatin can reduce blood lipids in patients with premature coronary heart disease and acute myocardial infarction,reduce inflammation and improve endothelial function ,they have similar short-term efficacy,but rosuvastatin has stronger lipid-lowering effect and reducing inflammatory function . Key words: Coronary artery disease; Rosuvastatin ; Atorvastatin ; Endothelium, vascular; Heart function tests