Comparison of the curative effect of insulin glargine combined with insulin lispro and combined with insulin aspart on T2DM and corresponding influence on blood glucose fluctuation and blood glucose excursion

Abstract

Objective To compare the curative effect of insulin glargine combined with insulin lispro and combined with insulin aspart on type 2 diabetes mellitus (T2DM), and study the corresponding influence on blood glucose fluctuation and blood glucose excursion. Methods A total of 70 patients with T2DM who were hospitalized in the People’s Hospital of Huozhou from July 2015 to July 2017 were randomly divided into observation group (n=35) and control group (n=35) according to their order of admission. Patients in observation group were treated with insulin glargine combined with insulin lispro, and patients in control group were treated with insulin glargine combined with insulin aspart. Levels of fast blood glucose (FBG), 2-hour postprandial blood glucose (2 h PG), glycosylated hemoglobin (HbA1c), fasting insulin (Fins) secretion, islet β-cell function index (HOMA-β), insulin resistance index (HOMA-IR) and total treatment response rate were compared between the two groups 12 weeks after treatment. The average blood glucose level, amplitude of blood glucose excursion, blood glucose excursion coefficient, time of reaching target of blood glucose, daily amount of insulin for reaching target of blood glucose and the incidence of hypoglycemia of the two groups were calculated. Results The curative effect was significantly better in observation group than control group 12 weeks after treatment (P 0.05). The levels of Fins and HOMA-β were significantly increased, while levels of FBG, 2 h PG, HbA1c and HOMA-IR were significantly decreased in both groups after treatment (P<0.05), and changes in above indicators were more obvious in observation group (P<0.05). Conclusions Compared with insulin glargine combined with insulin aspart, insulin glargine combined with insulin lispro can control blood glucose fluctuation, reduce blood sugar excursion and the incidence of hypoglycemia, and control blood glucose more effectively. Key words: Insulin glargine; Insulin lispro; Insulin aspart; Type 2 diabete mellitus; Blood glucose fluctuation