Analysis of efficacy of the treatment of insulin glargine combined with oral hypoglycemic drugs for type 2 diabetic patients using premixed insulin therapy

Abstract

Objective To evaluate the efficacy and safety of the treatment of insulin glargine combined with oral hypoglycemic drugs (OADs) for type 2 diabetic patients with poor glycemic control using premixed insulin therapy.Methods Fifty cases of poor blood glucose control patients with type 2 diabetes using 30/70 premixed insulin alone or in combination with OADs were randomly divided into treatment group ( converting premixed insulin into insulin glargine plus OADs,n =30) and control group ( continue to use the premixed insulin plus OADs,n =20).All groups were adjusted the dosage of insulin and OADs based on the levels of blood glucose.After 12 weeks,monitoring and comparing fasting blood glucose(FBG),2 hour postprandial blood glucose(2 h PG),glycosylated hemoglobin A1c(HbA1c) levels,body mass index(BMI) and the incidence of hypoglycemia during the test of the two groups.Results Compared with those before treatment,HbA 1 c,FBG,2 h PG of both groups have declined ( all P ＜ 0.01 ).The treatment group and control group have no significant change in BMI (P ＞ 0.05 ).Compared with the control group,FBG,lunch 2 h PG,BMI and HbAlc of the treatment group is lower ( all P ＜0.01 ).The incidence of hypoglycemia during the test of the treatment group is lower( P ＜ 0.01 ).Conclusions The treatment of insulin glargine combined with OADs for poor glycemic control in type 2 diabetic patients using premixed insulin,can significantly improve the levels of FBG and HbA 1 c,do not increase body weight,and it is simple to use,therefore can significantly reduce the risk of hypoglycemia. Key words: Type 2 diabetes mellitus; Premixed insulin; Insulin glargine