Clinical efficacy of insulin glargine combined with oral hypoglycemic agents in the treatment of type 2 diabetes mellitus

Abstract

Objective To evaluate the efficacy and safety of insulin glargine combined with oral hypoglycemic agents in the treatment of type 2 diabetes mellitus (T2DM). Methods From December 2012 to December 2016, 60 patients with T2DM in Shuozhou Infectious Disease Hospital were divided into observation group and control group according to the random number table, with 30 cases in each group.The control group received premixed insulin(insulin aspart 30) combined with glimepiride treatment, the observation group was treated with insulin glargine combined with glimepiride for 12 weeks.The blood glucose index, fasting blood glucose(FBG), postprandial 2 hours blood sugar(2hPG), glycosylated hemoglobin(HbA1c), plasma insulin(FINS) and insulin resistance index(HOMA2-IR) were compared between the two groups before and after treatment. Results After treatment, the FBG[(5.87±1.52)mmol/L vs.(6.79±1.98)mmol/L], 2hPG[(6.87±1.31)mmol/L vs.(7.89±1.65)mmol/L] and HbA1c[(7.14±1.18)% vs.(7.99±1.27)%] in the observation group were significantly better than those in the control group, the differences were statistically significant(t=4.636, 4.795, 3.896, all P<0.05). The FINS [(6.12±1.35)IU/mL vs.(7.38±1.65)IU/mL] and HOMA-IR[(2.80±0.29) vs.(3.21±0.34)] in the observation group improved significantly better than those in the control group, the differences were statistically significant(t=5.646, 3.926, all P<0.05). The incidence rate of hypoglycemia in the observation group was significantly lower than that in the control group(9.5% vs.37.8%), the difference was statistically significant(χ2=4.464, P<0.05). Conclusion Insulin glargine can significantly improve blood glucose levels and glycosylated hemoglobin levels, and help to improve insulin resistance in patients with T2DM.The incidence rate of hypoglycemia is low and the safety of the drugs is high. Key words: Diabetes mellitus, Type 2; Hypoglycemia; Glargine; Insulin