Comparison of analepsia effect of high and low dose sevoflurane combined with propofol in partial hepatectomy

Abstract

Objective To study the analepsia effect of high and low dose sevoflurane combined with propofol anesthesia in partial hepatectomy. Methods 64 patients with partial hepatectomy were selected as the subjects.They were randomly divided into low concentration group and high concentration group, 32 patients in each group.The two groups were treated with sevoflurane combined with propofol anesthesia, low concentration group was given 0.5MAC sevoflurane, high concentration group was given 1.0MAC sevoflurane.The clinical results were compared between the two groups. Results The time of propofol use, postoperative recovery time, extubation time and improved Aldrete score of 9 min in the high concentration group were (765.83±342.86)mg, (21.39±8.23)min, (41.81±8.37)min and (30.24±9.63)min, respectively, which were significantly lower than those in the low concentration group [(1 143.64±374.64)mg, (25.46±7.98)min, (46.68±7.73)min and (35.94±8.89)min, respectively, t=4.208, 0.008, 2.418, 2.460, all P<0.05]. In addition, the OAA/S scores at T0, T1of the high concentration group were (3.83±0.64)points and (4.28±0.85)points, respectively, which were significantly higher than those of the control group[(3.36±0.76) points and (3.79±0.87) points], the differences between the two groups were statistically significant (t=2.676, 2.279, all P<0.05). Conclusion The combination of sevoflurane and propofol in patients with partial hepatectomy can reduce the dosage of propofol and shorten the recovery time of postoperative spontaneous breathing in patients, and contribute to improve the quality of patients' recovery. Key words: Sevoflurane; Propofol; Anesthesia