Comparative analysis of efficacy of sequential therapy combined with probiotics, pure sequential therapy and standard triple therapy for Helicobacter pylori eradication

Abstract

Objective To compare the efficacy of sequential therapy combined with probiotics, pure sequential therapy and standard triple therapy for Helicobacter pylori eradication. Methods Selected the clinical data of 240 patients admitted. The 240 patients were randomly divided into 3 groups. Group A received standard triple therapy, group B received sequential therapy and Group C received sequential therapy in combination with probiotics. Then, we compared the eradication rate, the score of gastrointestinal tract symptoms before and after treatment, and the side effects among 3 groups. Results The eradication rate was 72.5%in group A,87.5%in group B,and 96.3%in group C. The eradication rate of group C was significantly better than group A and group B(χ2=18.531,P 0.05), but they all significantly decreased after treatment among 3 groups(P<0.05),with group C a better result(F=25.581,P<0.05).The side effects of 3 groups were 16.3%,13.8%,3.8%,respectively. There were a significantly differencec between group C and the other 2 groups(χ2=7.011,P=0.030). Conclusion Sequential therapy in combination with probiotics can achieve a higher eradication rate, improve the score of gastrointestinal tract symptoms, and decrease side effects. Key words: H.pylori; sequential therapy; probiotics