Effect of standard triple therapy combined with probiotic therapy and bismuth quadruple therapy on Helicobacter pylori

Abstract

Objective To investigate the effect of standard triple therapy combined with probiotic therapy and bismuth quadruple therapy on eradication rates and adverse effects of Helicobacter pylori (Hp). Methods One hundred and one patients with Helicobacter pylori infection were randomly divided into the control group(50 cases) and the observation group (51 cases). The control group was treated by bismuth quadruple therapy, the observation group was treated with amoxicillin, clarithromycin and ray Bella by standard triple therapy combined with probiotics treatment. Before and after treatment, the clinical symptom score, quality of life score and Hp eradication rate, adverse reaction rate and recurrence rate were observed and compared between the two groups. Results The clinical symptom scores of the observation group were lower than those of the control group at 1 week and 2 weeks after treatment, the differences were significant (P 0.05). The incidence of adverse reactions in the observation group was 7.84%, which was lower than that in the control group (22.00%), the difference was significant (P 0.05). After treatment, the quality of life of the observation group was higher than that of the control group, and the difference was significant (P<0.05). Conclusions The eradication rate of Helicobacter pylori is high in the standard triple therapy based on bismuth or probiotics treatment, and the recurrence rate is low, but the adverse reaction rate of the standard triple therapy combined with probiotics therapy is lower, which can improve the quality of life of patients. Key words: Standard triple therapy; Probiotics; Bismuth quadruple therapy; Helicobacter pylori