Abstract
In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to the Editor we discuss these inaccuracies to correct the scientific record. When the science is recounted accurately it does not support Saber et al’s statements and conclusions.
Highlights
In their Commentary Saber et al (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials
Driscoll et al Particle and Fibre Toxicology (2020) 17:33 observed at high lung burden” and “particle clearance rates in mice, hamsters and rats depend on the lung burden: lower clearance rates are observed with increasing lung burden, but the impaired clearance is only observed in rats”
Elder et al observed a significant, dose-dependent impairment of lung particle clearance in rats, mice and hamsters exposed for 13 weeks by inhalation to carbon black (CB)
Summary
In their Commentary Saber et al (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. In the Commentary by Saber et al [1] the authors argue that “the chronic inhalation study in rats can be used for assessing the lung cancer risk of insoluble nanomaterials”. Saber et al cite reports by Mauderly et al [2] and Heinrich et al [3] which summarize results of chronic inhalation studies in rats.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
