Abstract
The paper describes a chronic (18-month) inhalation study in rats, comparing respiratory tract lesions produced by exposures to cigaretts with different inclusion of Cytrel®, a tobacco supplement. Histopathological examinations indicated lower responses in animals exposed to Cytrel-containing cigarettes than in those exposed to all-tobacco cigarettes, despite similar total deliveries of smoke. The decrease in response was approximately proportional to the level of Cytrel inclusion.
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