Combined application of bone imaging and t-PSA, f-PSA, ALP in the diagnosis and treatment of bone metastases in patients with prostate cancer

Abstract

Objective To explore the clinical value of combined application of bone imaging and prostate specific antigen(t-PSA), free prostate specific antigen(f-PSA) and alkaline phosphatase(ALP) in the diagnosis and treatment of prostate cancer bone metastasis. Methods The data of 372 patients diagnosed of prostate cancer were reviewed, and the results of the whole body bone scan and t-PSA, f-PSA, ALP were analyzed retrospectively. Results 282 cases in 372 cases of prostate cancer were diagnosed as bone metastasis.The t-PSA, f-PSA and ALP of prostate cancer patients with metastasis were significantly higher than those of prostate cancer patients without metastasis, the difference was statistically significant (P<0.05). The sensitivity of bone imaging in the diagnosis of bone metastases was 91.84%, the specificity was 76.67%, the accuracy was 88.17%, the positive predictive value was 92.50%, the negative predictive value was 75.00%.The combined application of bone scan and serum t-PSA, f-PSA, ALP detection, the sensitivity of the diagnosis of bone metastasis of prostate cancer was 95.71%, specificity was 87.69%, accuracy was 94.36%, the positive predictive value was 87.56%, the negative predictive value was 92.22%. Conclusion Combined application of whole body bone scan and serum t-PSA, f-PSA, ALP detection has high sensitivity and accuracy in diagnosis of bone metastasis of prostate cancer, and it can provide reliable basis for early diagnosis, treatment and prognosis of prostate cancer. Key words: Prostate neoplasm; Prostate specific antigen; Free prostate specific antigen; Alkaline phosphatase; Bone metastasis