Study of relationship between the bone imaging, level of PSA and pathology grade in diagnosis of prostate carcinoma bone metastasis

Abstract

objective To investigate the relationship between the level of serum prostate-specific antigen (PSA),pathology grade and bone imaging in diagnosis of bone metastasis in prostatic carcinoma.Methods Serem PSA.whole body bone imaging with 99Tcm-methylene diphosphonate,pathology grade in 107 cases of prostatic carcinoma were retrospectively reviewed as to their correlation with bone metastasis.Results Fourty-nine of 107 cases demonstrated bone metastasis by whole body bone imaging.There were significant difference in bone metastasis incidence rate among high differentiation group,middle differentiation group and low differentiation group.The results showed that when PSA 2 μg/L,bone metastasis should be considered and bone imaging Was necessary.Conclusions There were some relationship among the level of PSA,pathology grade and bone metastasis.The possibility of bone metastasis became high when PSA>20 μg/L.If PSA>60 μg/L,a clinical diagnosis of bone metastasis might be made. Key words: Prostatic neoplasms; Neoplasm metastasis; Bone; Technetium Tc 99m medronate; Prostate-specific antigen