Clinical value of detection of homocysteine and high sensitive C reactive protein in diagnosis of patients with acute cerebral infarction

Abstract

Objective To explore the application value of combined detection of homocysteine (Hcy) and high sensitive C reactive protein (hs-CRP) in diagnosis of patients with acute cerebral infarction (ACI). Methods 15 cases with ACI were selected as the study group.According to Hamilton Depression Scale (HAMD), the patients were divided into depression group (n=5) and non-depression group (n=10), another 15 healthy persons were selected as control group.The fasting venous blood was extracted in the early morning, the levels of Hcy and hs-CRP were detected by enzyme linked immunosorbent assay and turbidimetry, and the results were analyzed. Results The serum levels of Hcy and hs-CRP in the study group were (16.70±2.65)μmol/L, (10.16±1.08)mg/L, respectively, which were significantly higher than those in the control group, the differences were statistically significant (t=8.55, 9.31, all P<0.05). The serum levels of Hcy and hs-CRP in the moderate group were (16.28±2.09)μmol/L, (10.23±1.32)mg/L, respectively, which were significantly higher than those in the mild group, the differences were statistically significant (t=6.75, 8.56, all P<0.05). The serum levels of Hcy and hs-CRP in the severe group were (20.54±2.54)μmol/L, (15.10±1.49)mg/L, respectively, which were significantly higher than those in the mild group and moderate group, the differences were statistically significant (t=6.64, 7.88, t=6.69, 6.44, all P<0.05). The serum Hcy, hs-CRP levels in patients with middle cerebral infarction group were (15.78±1.56)μmol/L, (10.54±1.67)mg/L, respectively, which were significantly higher than those in the small infarction group, the differences were statistically significant (t= 6.36, 7.83, all P<0.05). The serum Hcy, hs-CRP levels in the patients with large infarction group were (21.77±2.05)μmol/L, (16.76±1.79)mg/L, respectively, which were significantly increased compared with the small infarction group and the middle infarction group, the differences were statistically significant(t=6.70, 7.55, t=6.46, 6.65, all P<0.05). The serum levels of Hcy and hs-CRP in ACI patients with depression were (19.98±2.69)μmol/L and (14.06±1.93)mg/L, respectively, which were significantly higher than those in the non-depression group (t=6.87, 7.50, all P<0.05). Conclusion Detection of Hcy and hs-CRP has high application value in the early prevention and diagnosis of patients with ACI, it is worthy of promoting. Key words: Homocysteine; C reactive protein; Acute cerebral infarction; Prevention; diagnosis